DPiMS-8060
A triple quadrupole mass spectrometer with a DPiMS-8060 kit installed can acquire trace sample quantities using a probe and analyze component masses in the MS unit. The kit can also be used with an LCMS system, by installing it in an LCMS-8045/8050/8060 system for easy switching between PESI TQ and ESI units. Its ability to quickly detect drugs or metabolites in blood or tissue samples with only extremely simple pretreatment makes it ideal for simple screening applications.
Category:
Producer:
Product Description
A triple quadrupole mass spectrometer with a DPiMS-8060 kit installed can acquire trace sample quantities using a probe and analyze component masses in the MS unit. The kit can also be used with an LCMS system, by installing it in an LCMS-8045/8050/8060 system for easy switching between PESI TQ and ESI units. Its ability to quickly detect drugs or metabolites in blood or tissue samples with only extremely simple pretreatment makes it ideal for simple screening applications.
Technical specifications
Measure a Variety of Samples with Only Simple Pretreatment
Rapid and Easy Drug Detection in Forensic Samples.
- Place a piece of each organ on a biological sample plate and add 50 % ethanol (35 μL).
- Detection is possible by on-plate MRM / Product Ion Scan analysis.
Dedicated Method Package for DPiMS-8060
When using this method package with the DPiMS-8060 for mass analysis, it is no longer necessary to spend time and effort considering analysis conditions or optimizing MS parameters for each compound before starting the analysis. The simultaneous analysis of several compounds can be carried out much more efficiently.
Metabolomic Analysis Performed Easily
by Transferring LCMS Analytical Conditions to DPiMS Unit
In this example, transition information for metabolites (26 components) such as amino acids, organic acids, and sugars were used for metabolomic analysis of mouse livers. Metabolomes can be analyzed easily by customizing some of the analytical conditions in the LCMS primary metabolite method package. The DPiMS-8060 system was used to measure the principal components in the model mouse group with acute liver damage induced by carbon tetrachloride and the control group. A significant difference was observed between model and control groups (given p < 0.001 for Welch's t-test), based on the significant contribution of taurine to the separation of groups in the PCA loading plot. The difference was verified with a box-whisker plot.
Enables Use of LC/MS/MS Method Package
The DPiMS-8060 system uses a direct analysis method that does not involve liquid chromatography using probe electrospray ionization. MRM parameters can be specified based on transition information included in the LC/MS/MS method package.
Consequently, methods can be created easily using an Excel template. A key feature of PESI is the easy process flow from pretreatment to measurement. For more detailed analysis, the ionization unit can be replaced with the ESI unit for measurements as an LC/MS/MS system.
Data Analyzed Using LabSolutions LCMS
The system can be used for a wide variety of applications, such as for library searches based on mass spectra obtained from product ion scans, for quantitative analysis based on ion chromatograms obtained from MRM, or for multivariate analysis using scan data.
Because the postrun analysis functionality in LabSolutions LCMS is used, data can also be easily compared to LC/MS/MS data.
Highly resistant to MS contamination, even with complex matrices.
Analysis System with No Carryover
Only a tiny amount of sample attaches to the probe during each sampling, reducing the risk of contamination inside the mass spectrometer to near zero.
Carryover can even be prevented by changing probes.
Even concentrated samples or samples of unknown concentration can be measured directly without pretreatment.
