LCMS-9050
The LCMS-9050 is a quadrupole Time-of-Flight (QTOF) mass spectrometer system designed with technologies developed for Shimadzu LCMS series models and that results in among the highest mass accuracy stability levels available.
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Product Description
The LCMS-9050 is a quadrupole Time-of-Flight (QTOF) mass spectrometer system designed with technologies developed for Shimadzu LCMS series models and that results in among the highest mass accuracy stability levels available.
Technical specifications
Simpler Accurate Mass Spectrometry
Technologies inherited from the Shimadzu LCMS series
The LCMS-9050 provides excellent performance thanks to Shimadzu’s proprietary patented technology inherited from the LCMS series. The system is equipped with technology mainly inherited from the LCMS-8000 series, from the injection unit to the ion separator. Ions are efficiently injected into the TOF unit thanks to the bright ion optical system and high ion convergence. At the TOF unit, the precision temperature control system inhibits mass accuracy variations caused by external factors. The heater and temperature sensor are arranged at the optimal flight tube positions, providing highly accurate and robust temperature control. In addition, the electrical system controlling the flight tube is temperature controlled to achieve high mass stability.
Stable long-term mass accuracy
The precision-controlled temperature control system minimizes the effects of room temperature variations, so the LCMS-9050 provides extremely stable mass accuracy. For this reason, the system can be used to measure accurate mass values easily, without worrying about mass calibration. In addition, the time and effort expended to date on frequent mass calibration can be reduced.
Under usual laboratory conditions, six antibiotics (with molecular weights between 265 and 1203 Da) were consecutively analyzed, and the mass error against the theoretical values was plotted. When the compounds were analyzed three at a time in positive ion mode and negative ion mode, the mass accuracy was stable with accurate mass values for all compounds to within ± 2 ppm of the theoretical values without calibrating mass even once in 72 hours.
Effortless tuning (Performance Assistant)
A sub-probe separate from the main probe is included as standard with the LCMS-9050. The ionization unit is equipped with two probes, one for analysis and one for mass calibration, so the ionization unit does not need to be replaced during mass calibration or other equipment tuning. In addition, analysis and tuning can be performed without worrying about flow line contamination. Multiple sample vials can be stored in the unit, so the system can accommodate multiple calibration samples.
The LCMS-9050 includes an auto-tuning function that uses a standard sample to automatically adjust mass accuracy, resolution, sensitivity, and other parameters.
The function includes various tuning modes that can be selected depending on the instrument status, such as the full-tuning mode for tuning the entire system or other modes for tuning only the TOF unit for mass calibration. Auto-tuning can be executed from the LabSolutions™ LCMS workstation software without configuring any complicated settings, which means anyone can start an analysis with the system adjusted to its optimal state.
Provides High-Speed Polarity Switching Even with TOF
New Shimadzu technology: UFstabilization™
When switching between positive ion mode and negative ion mode, the flight tube voltage changes continuously to the target value. Mass errors will occur if analysis is performed before the voltage reaches the target value, so a stabilization standby time is required when switching polarity. With previous models, a certain amount of time was needed for stabilization standby, which made simultaneous positive ion/negative ion analysis difficult.
The LCMS-9050 provides high-speed polarity switching by substantially shortening the time required for stabilization standby during polarity switching. This is due to a high voltage power supply developed in-house by concentrating Shimadzu’s LCMS history and technology, and a proprietary polarity switching algorithm (patented) developed by thoroughly investigating the properties of the high voltage power supply. Stable mass accuracy is shown even during high-speed positive/negative polarity switching, enabling simultaneous positive ion/negative ion analysis.
Stability and high mass accuracy
Just as with unipolar analysis, under usual laboratory conditions, six standard antibiotics (with molecular weights between 265 and 1203 Da) were subjected to simultaneous positive/negative ion analysis during a single analysis. The sub-interface was used to inject the external standard. Consecutive analyses were implemented until the external standard was used up, and a mass accuracy of within ±3 ppm was indicated for all compounds. Stable mass accuracy was maintained, even when performing long-term consecutive analyses using positive/negative ionization switching mode.
A world of new applications
With QTOF to date, when positive ion analysis and negative ion analysis were both performed, two measurements in total were required for the respective analyses, but with the LCMS-9050, the process is completed with a single measurement.
Analysis data accuracy is improved, because with pretreated samples under the same conditions, the positive/negative ions can be detected with no time difference. In addition, information on positive/negative ions can be obtained from a single analysis even for trace samples, which reduces the amount of reagents used. The data is output in a single data file, which makes it easy to compare the positive ion/negative ion analysis results.